BRCA1/2 mutations markedly increase cancer risk in women for which cancer besides breast cancer?

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Multiple Choice

BRCA1/2 mutations markedly increase cancer risk in women for which cancer besides breast cancer?

Explanation:
When BRCA1 and BRCA2 fail to properly repair double-strand DNA breaks, cells accumulate genetic damage that increases cancer risk. In women, the cancer most markedly linked to BRCA1/2 mutations, aside from breast cancer, is ovarian cancer. Carriers have a substantially higher lifetime risk of ovarian cancer than the general population, with BRCA1 often conferring a higher risk than BRCA2. The link is strongest because the ovarian surface epithelium and related tissues are particularly susceptible to malignant transformation when DNA repair is compromised. While BRCA mutations can raise risk for other cancers (such as pancreatic cancer, especially with BRCA2), none are as strongly associated as ovarian cancer in women. Prophylactic options like oophorectomy can markedly reduce this risk.

When BRCA1 and BRCA2 fail to properly repair double-strand DNA breaks, cells accumulate genetic damage that increases cancer risk. In women, the cancer most markedly linked to BRCA1/2 mutations, aside from breast cancer, is ovarian cancer. Carriers have a substantially higher lifetime risk of ovarian cancer than the general population, with BRCA1 often conferring a higher risk than BRCA2. The link is strongest because the ovarian surface epithelium and related tissues are particularly susceptible to malignant transformation when DNA repair is compromised. While BRCA mutations can raise risk for other cancers (such as pancreatic cancer, especially with BRCA2), none are as strongly associated as ovarian cancer in women. Prophylactic options like oophorectomy can markedly reduce this risk.

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