Which statement about high-risk screening protocols is true?

• A. Mammography every year and MRI every five years
• B. Mammography every six months and annual MRI with contrast
• C. Mammography every two years with no MRI
• D. MRI only, no mammography

Answer: (B)

In high‑risk screening, using more than one imaging method boosts the chance of catching cancer early. MRI with contrast is more sensitive than mammography, especially in women with dense breasts or genetic risk, so it’s recommended in addition to mammography to improve detection. The statement that combines regular mammography with an annual MRI with contrast reflects this multimodal approach: you get the wide coverage of mammography and the higher sensitivity of MRI to pick up cancers that mammography might miss. The other options rely on either too little use of MRI, or on MRI alone, or on infrequent imaging, which would miss cancers more often in high‑risk individuals.